Hey Bigg3r;
A good read. I am a firm believer in BCAA’s in that Leucine, part of the chain does indeed help in further driving muscle protein systhesis and help in the recovery process. I do take BCAA’s before and after my w/o’s and on OFF days but, noted that under Conclusions it is stated that:
“-BCAAs do not increase protein synthesis, but decrease protein breakdown.” However, under
The Role of Leucine and
A better net protein balance, there seems to be a contradiction regarding the above conclusion.
The Role of Leucine )Leucine appears to exert a synergistic role with insulin as a regulatory factor in the insulin/ phosphatidylinositol-3 kinase (PI3-K) signal cascade. Insulin serves to activate the signal pathway,
while leucine is essential to enhance or amplify the signal for protein synthesis at the level of peptide initiation (E1).
2)If only a single stimulatory amino acid is given (e.g. leucine), after the initial anabolic stimulation, all of the other amino acids show a fall in their concentration, and leucine oxidation rises, presumably because complete proteins can no longer be made (P2).
3)Leucine is suggested to be able by itself to stimulate MPS in animal and human muscle. These results are consistent with such a role for leucine; however, its behaviour was indistinguishable from that of the other branched-chain amino acids, and indeed of the EAAs as a whole (P2).
A better net protein balance -Leucine+carbs+protein following 45 min of resistance exercise:
Mixed muscle FSR, measured over a 6-h period of post exercise recovery, was significantly greater in the CHO+PRO+Leu trial compared with the CHO trial (0.095 +/- 0.006 vs. 0.061 +/- 0.008%/h, respectively, P < 0.05), with intermediate values observed in the CHO+PRO trial (0.0820 +/- 0.0104%/h) (K31).
-Administration of an amino acid-glucose mix increases phenylalanine net balance (-27 ± 8 to 64 ± 17).
Muscle protein synthesis increased (61 ± 17 to 133 ± 30 (P = 0.005). Protein breakdown decreased (P = 0.012) and leg glucose uptake increased (P = 0.0258) with the mixture (K23).
Peace