Human Trials of Myostatin inhibitor have begun!!!!!!!!!!!!!
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Human Trials of Myostatin inhibitor have begun!!!!!!!!!... - 12/15/2005 11:11:50 AM
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Mathiastheok
Posts: 8
Joined: 12/11/2005
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This IS the next step many of us have been waiting for.
The trials are of course being done on humans with muscle wasting disseases, as they have a moral right to have their issues solved first...I will gladly wait for those drugs to be developed for them, and THEN lets see what we can do for those of us who want to take our bodies to the next level...
The link to the article: http://www.fshsociety.org/fsh/MYO029SitesFSHD.html
I would also like to interject my opinion of how this will affect the sports world. I think this way.. IF I was competing (I am a 60% disabled Veteran..so I just need the health benefis of this type of therapy), but, again, if I was competing against lets say any athlete with a NATURAL genetic makeup that supresses or has less myostatin, then I AM AT AN UNFAIR DISADVANTAGE. And by this factor, Flex Wheeler, whom I believe it has been proven that he also exhibits this type of myostatin blockage, HAS an UNFAIR advantage over the other bodybuilders.
I think that leveling the Myostatin field will actually CREATE more FAIR competition. Thanks.
PS for your information, the name of the HUMAN myostatin inhibitor is: MYO-029 Please use this name when searching for information, as you may very well be pulling up eithor old informaiton or information on a myostatin inhibitor that is not for humans.
< Message edited by Mathiastheok -- 12/15/2005 11:15:39 AM >
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RE: Human Trials of Myostatin inhibitor have begun!!!!!... - 12/15/2005 11:19:02 AM
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Mathiastheok
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Joined: 12/11/2005
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Here is the US GOV. Clinical trials website with the informaiton on this trial: http://clinicaltrials.gov/ct/show/NCT00104078?order=3
Also here is how the clinical phase trial you always hear about are set up:
Study Phase Most clinical trials are designated as phase I, II, or III, based on the type of questions that study is seeking to answer: - In Phase I clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
- In Phase II clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
- In Phase III studies, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
(in reply to Mathiastheok)
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RE: Human Trials of Myostatin inhibitor have begun!!!!!... - 12/15/2005 1:26:28 PM
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Mathiastheok
Posts: 8
Joined: 12/11/2005
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Please define "suplimenting" if you mean by some form of oral pill or powder or drink, than yes, those are all scams and will never work.
Introducing someting at the "genetic" level or cellular level with a harmless virus as the "taxi" it is very easy, has been proven multiple times in humans and lab rats (NOT by heridity...but by injection..In Vivo instead of In Vitro) and has been proven to work. Now, the excitement is to see if it will work in humans. If it does then and only then should we really start getting excited.
Understand, this will most likely be a prescription only drug, which like any other prescription drug can be obtained without one, but look at all of the welness clinics out there. If your over 30 you can sign right up and get Test and HGH etc.. prescribed to you by a doctor for the purpose of looking and feeling good!
If the clinical trials prove sucessful, decreasing your muscles collection of myostatin will be like getting plastic surgery...cosmetic inprovement..BUT with complete functionality!!
< Message edited by Mathiastheok -- 12/15/2005 8:56:25 PM >
(in reply to Misanthropy)
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RE: Human Trials of Myostatin inhibitor have begun!!!!!... - 12/15/2005 3:23:02 PM
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velikimajmun
Posts: 35
Joined: 11/17/2005
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quote:
Introducing someting at the "genetic" level or cellular level with a harmless virus as the "taxi" it is very easy, has been proven multiple times in humans and lab rats (NOT by heridity...but by injection..In Vivo instead of In Vitro) and has been proven to work. Now, the excitement is to see if it will work in humans. If it does then and only then should we really start getting excited.
Gene therapy is anything but easy. It has proven unpredictable and uncontrollable. There have been dozens of clinical trials, most of which have been considered failures for a host of reasons. Most in the scientific community feel that the field of gene therapy is dead or dying (some would say it died with jesse gelsinger). If we do see gene therapy in routine clinical use it will only likely be for severe genetic diseases such as SCID. It won't work for myostatin as the goal for myostatin is to eliminate or block myostatin. Current gene therapy can add a gene but deleting one is considerably more difficult.
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(in reply to Mathiastheok)
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RE: Human Trials of Myostatin inhibitor have begun!!!!!... - 12/15/2005 8:47:54 PM
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Mathiastheok
Posts: 8
Joined: 12/11/2005
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I am sorry bit I think you are ill informed. Please do not take that as an insult..I in no way mean it like that.
You see, no gene manipulation is being done. This is not gene therapy by any means.
What the scientists are going to inject is the business end of a cellular docking point for the myostatin protein, and it works in part by mopping up myostatin so it can't exert its muscle-inhibiting influence.
So you see, there is no manipulation of any genes what so ever. Merly we are introducing an agent into our bodies that will move around a "collect" the myostatin preventing it from preventing our muscles from growing.
It has also been proven to be non oncogenic, or non cancer forming..it cant as the process of mopping up the myostatin doesnt produce any free radicals (Dead cellular "junk" that builds up in our bodies and can lead to cancer..which is why Antioxidents are soo good to combat this)
I mean I can get really crazy here and tell you about Telomerase and how it ALLREADY in the lab had allowed HUMAN cells to LIVE INDEFINATLY with those cells still dividing to this day. Telomerase is what makes cancer so damn near impossible to kill... well, we can activate the same gene in ourselvs to make us as resiliant as cancer...and yes Geron corp (one of many) is working on the cancer CURE by simply stopping the cancer cell from producing telomerase.
(in reply to velikimajmun)
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RE: Human Trials of Myostatin inhibitor have begun!!!!!... - 12/15/2005 9:05:26 PM
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Marc David
Posts: 6742
Joined: 4/6/2003
From: Bay Area -CA
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You can use the block button below your avatar.
However, after reviewing these posts, and while I don't think much of Myostatin, I don't see any blatent advertising other then to bring up some posts and articles about this discovery that has been around on various supplement discussions.
The links (ads) were to stuides or articles on various news and related sites.
While I cannot debate the validity, I think it's a valid topic for those who are interested and may want to table this discussion.
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(in reply to chrisshepherd)
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RE: Human Trials of Myostatin inhibitor have begun!!!!!... - 12/15/2005 9:36:42 PM
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Mathiastheok
Posts: 8
Joined: 12/11/2005
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I apologise chrisshepherd for any confusion that I may be an advertizer. The only business I own is Government Supply Specialists .. I supply things to the federal government. Thats it. And I am a disabled veteran, 60% with degenerative spinal dissease and about 12 broken disks in my spine. Please trust me when I say that my ONLY intention is to discuss this new scientific development. Unfortunatly up untill now I have only been correcting some people, and or sharing some information they may not have been aware of. If there is a place on the web where I may direct people to medical articles without any advertisment, please let me know and I will do my best to use it.
The sites I posted above were the Medical News Today, a free web e-zine, the facioscapulohumeral muscular dystrophy society a non profit .org organization, and the clinicaltrials.gov website, a Government website. I dont believe they have any ads on any of the pages I posted above.
I want to be polite, but I think you are being a bit unfair.
< Message edited by Mathiastheok -- 12/15/2005 9:44:05 PM >
(in reply to chrisshepherd)
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RE: Human Trials of Myostatin inhibitor have begun!!!!!... - 12/16/2005 5:30:51 AM
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velikimajmun
Posts: 35
Joined: 11/17/2005
Status: offline
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quote:
ORIGINAL: Mathiastheok
I am sorry bit I think you are ill informed. Please do not take that as an insult..I in no way mean it like that.
You see, no gene manipulation is being done. This is not gene therapy by any means.
What the scientists are going to inject is the business end of a cellular docking point for the myostatin protein, and it works in part by mopping up myostatin so it can't exert its muscle-inhibiting influence.
So you see, there is no manipulation of any genes what so ever. Merly we are introducing an agent into our bodies that will move around a "collect" the myostatin preventing it from preventing our muscles from growing.
It has also been proven to be non oncogenic, or non cancer forming..it cant as the process of mopping up the myostatin doesnt produce any free radicals (Dead cellular "junk" that builds up in our bodies and can lead to cancer..which is why Antioxidents are soo good to combat this)
I mean I can get really crazy here and tell you about Telomerase and how it ALLREADY in the lab had allowed HUMAN cells to LIVE INDEFINATLY with those cells still dividing to this day. Telomerase is what makes cancer so damn near impossible to kill... well, we can activate the same gene in ourselvs to make us as resiliant as cancer...and yes Geron corp (one of many) is working on the cancer CURE by simply stopping the cancer cell from producing telomerase.
You misread or entirely misunderstood my post. I was refering to your comments on gene therapy not on the myostatin therapeutic. Telomerase is only a tiny piece of the cancer puzzle. I'm far from misinformed, I've published peer-reviewed articles on genetherapy vectors and have been doing biomedical research for the past ten years. I am working on my doctorate at the institute where the early breakthroughs in gene therapy took place. it's also the institute where the first death due to a genetherapy trial occurred. So feel free to stop with the silly condescending tone. Your comprehension of cell biology in minimal at best. Free radicals are not dead cellular junk, they aren't even biomolecules. immortalized human cell lines have existed for 60 years and we've known about telomerase for decades, targeting it in a cancer specific manner is the problem (one of many).
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(in reply to Mathiastheok)
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RE: Human Trials of Myostatin inhibitor have begun!!!!!... - 12/16/2005 6:48:15 AM
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tdf700
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Joined: 9/23/2005
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I have not read the articles he posted. These posts here seem to be informative and well thought out. Like I said I have not taken the time to verify what he has said, but if he is accurate then I am pleased to see someone so well informned posting.
(in reply to chrisshepherd)
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RE: Human Trials of Myostatin inhibitor have begun!!!!!... - 12/17/2005 9:15:50 PM
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Canadian_Ice_Monkey
Posts: 1
Joined: 12/17/2005
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I think that the two sides to this debate are missing each others points. I too have a background in celluar and molecular genetics. I dont see how how this discussion has moved from myostatin inhibitors in late phase trials to telomerase and immortal cell lines....Although there are connections, it is not a direct one.
Myostatin inhibitors when they do make it to the market will change the face of bodybuilding as we know it.
But as we all know, if works well its classsified as a drug, if its just so-so it's a supplement.
I dont think that we will be seeing effective myostat supplements in your local GNC any time soon.
...but thats just my two sense.
(in reply to tdf700)
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RE: Human Trials of Myostatin inhibitor have begun!!!!!... - 12/22/2005 10:11:18 PM
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DaddyDanDan
Posts: 255
Joined: 1/17/2005
Status: offline
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do you people realize how this all started out
yeah im very sorry about the spinal disk problem
the ironic thing is that yall are talkin about this myostatin thing like it is goin to "level the playin field"
people with this deficiency for instance the flex wheeler reference, sounds alot like what people are so mad at steroids for
that steroids level the playin field
guys if it is labeled as a drug it is in the same category as the "steroids" that are so horrible
this is my two cents on this topic also
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If weightlifting was easy, everyone would do it
You gotta lift BIG, to get BIG
Doesn't matter how much you lift but how you lift it
(in reply to Canadian_Ice_Monkey)
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