Genric Gakic...Why?

zach next time you make up bull**** stats try to make them a little more believable. it has destroyed any credabilty you have (not much anyways but even thats gone)

i want to be like marc david when i grow up

ORIGINAL: Cgrim454

hey guys i work at a vitamin shoppe, i tried the stuff it does not work at all, alll hype......wasit fo money i thought it was gonna be the best thing and when i had it i was like wtf.....  and it doesnt even mix right....def not worth it 

 
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i think that company in ironman magazine made there own version...muscle-link....i remember reading there article on it...but i dont know how much it is....

10.5%
the question is is that enough to notice a difference?
thats only 10 lbs on 100

That has been my gakic battle-cry! lol. They say its this miracle supplement but 10.5% isnt very much!! Thats an awful lot of money so you cna lift an extra 10-20 lbs

STACK- Vaso-Pump, Acai Tablets ,Oryx Goat Whey, Cell-Tech Hardcore, Universal Animal Pak, EFA's

Size-5'10 - 180lbs
20 yrs -- Body Fat -- 7%

Athletic Training

found a medical article on Alpha-ketoglutarate

Description
Ornithine alpha-ketoglutarate (OKG) is a salt formed by combining two molecules of the amino acid ornithine and one molecule of alpha-ketoglutarate. Because OKG seems to be involved in amino acid synthesis and protein availability, many athletes supplement with OKG as a way to increase muscle mass and strength – although the evidence for its effectiveness is this regard is quite limited.

Claims

Increase muscle size and strength

Reduce body fat

Stimulates the immune system

Theory
OKG has been used to treat patients suffering from burns, surgery, malnutrition and other trauma. Although the precise mechanism is unknown, OKG treatment decreases muscle protein catabolism (breakdown) and/or increases protein synthesis, in addition to promoting wound healing. OKG may promote the secretion of anabolic hormones such as insulin and growth hormone and increase amino acid metabolism (glutamine & arginine), which may help explain some of the clinical findings.

Scientific Support
Arginine and ornithine are precursors of nitric oxide and polyamines, respectively -metabolites which participate in a number of metabolic functions. OKG supplements have been shown to promote growth hormone and insulin secretion with anabolic effects in postoperative patients. Their intermediary metabolites (glutamine & proline) may also have beneficial effects in promoting recovery from trauma. In animal studies, OKG supplementation increases levels of arginine and glutamine in skeletal muscles and stimulates immune system function compared to animals not receiving OKG. The immunomodulatory properties found with OKG suggest that it may enhance host-defense mechanisms, particularly during injury and acute stress. OKG supplements (15 grams per day for 5 months) have been shown to improve growth rates in small children. The OKG supplements resulted in elevated concentrations of anabolic (growth) hormones and amino acid metabolites, including insulin-like growth factor 1 (IGF1), glutamine and glutamate. In another study of healthy men, OKG given at 10 grams per day resulted in a 20-30% elevation in insulin (another anabolic hormone), which were not observed with supplementation of either ornithine or alpha-ketoglutarate alone. A test tube study found that OKG induces a significant increase in growth of human fibroblasts – cells with similarities to muscle fiber cells. This effect was dose-dependent, meaning that a more pronounced growth effect was noted with increasing levels of OKG (but not with increasing levels of ornithine or alpha-ketoglutarate alone). In one study, the anti-catabolic effects of OKG were investigated in 14 multiple trauma patients who were highly catabolic and hyper-metabolic. One group of subjects received 20 grams of OKG per day and showed a significant increase in protein turnover as well as a an increase in blood levels of insulin, growth hormone, and free amino acids (glutamine, proline and ornithine) compared to subjects not receiving OKG supplements.

Safety
No apparent side effects have been noted with OKG supplementation at the doses studied (10-15 grams/day), although there have been anecdotal reports of increased appetite – perhaps owing to elevated insulin levels (??).

Value
OKG supplements, taken at a dose shown to produce effects (10-15 grams per day) is a fairly expensive regimen. At $30-$35 per 100 capsule bottle (1250 mg capsules), a one month supply will cost over $100. For stimulating increases in muscle mass, creatine may be able to provide the same end benefit – at a much lower cost per day.

Dosage
OKG has been used at doses of 10-15 grams per day in healthy men and short-stature children.

References
1. Cochard A, Guilhermet R, Bonneau M. Plasma growth hormone (GH), insulin and amino acid responses to arginine with or without aspartic acid in pigs. Effect of the dose. Reprod Nutr Dev 1998 May-Jun;38(3):331-43. 2. Jeevanandam M, Petersen SR. Substrate fuel kinetics in enterally fed trauma patients supplemented with ornithine alpha ketoglutarate. Clin Nutr 1999 Aug;18(4):209-17.

<message edited by crazyest on Sunday, February 05, 2006 9:32 PM>

ORIGINAL: crazyest

a one month supply will cost over $100. For stimulating increases in muscle mass, creatine may be able to provide the same end benefit – at a much lower cost per day.

 
oh well i'll stick to my creatine

Really good article KUDOS!

STACK- Vaso-Pump, Acai Tablets ,Oryx Goat Whey, Cell-Tech Hardcore, Universal Animal Pak, EFA's

Size-5'10 - 180lbs
20 yrs -- Body Fat -- 7%

Athletic Training

I work at GNC (I know Booo Hisss) but I have had customers come in and say it worked for them. Not after one day but a week. As for the powder, it tastes like cack and when you try and mix it it has like gel like lumps in it. I do know we sell quite a bit of it and only one return so far and it was because of taste. I guess everyone is different and you just have to try it and see. You could always return it if you dont like it.

The Weaker Sex? I'll show you weak...

For the love of God people!

1. Lift
   
2. Eat
   
3. Sleep

Is there something that you do not understand?

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